Actinomycetes



BCRC Number: 11518
Organism: Streptomyces clavuligerus
Author: Higgens and Kastner
History: << NRRL << Eli Lilly Co.
Other Collection No.: ATCC 27064 ;CBS 226.75 ;DSM 738 ;DSM 41253 ;IFO 13307 ;IMET 43657 ;NCIMB 12785 ;NRRL 3585 ;JCM 4710
Source: soil, South America
Characterization:
Production : clavulanic acid U. S. Pat. 4,525,352
5-(2-aminoadipyl)cysteinylvaline synthetase (ACV synthetase) -- B9038;
penicillin G (benzylpenicillin) -- B9037;
penicillin N(synnematin B)--B375;
cephalosporins
cephalosporin antibiotics 7-(5-amino-5-carboxyvaleramido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid, and 7-(5-amino-5-carboxyvaleramido)-3-carbamoyloxymethyl -7-methoxy-3-cephem-4-carboxylic acid
Growth Conditions: 30°C
Biosafety Level: 1
Type Strain: YES
    Reference: B371
Shipping/Field/Price:
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References



B371
1971. Int. J. Syst. Bacteriol. 21: 331.
B375
1959. Antibiot. Chemother. 9: 614.
B9037
Luengo JM, Lopez-Nieto MJ, Salto F. 1986. Cyclization of phenylacetyl-L-cysteinyl-D-valine to benzylpenicillin using cell-free extracts of Streptomyces clavuligerus. J Antibiot (Tokyo). 39(8): 1144-1147.
B9038
Baldwin JE, Bird JW, Field RA, O'Callaghan NM, Schofield CJ, Willis AC. 1991. Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase. J Antibiot (Tokyo). 1991 Feb;44(2):241-8. 44(2): 241-248.
 

Medium



46
YEAST EXTRACT-MALT EXTRACT AGAR (ISP MEDIUM 2)
Yeast extract4.0 g
Agar20.0 g
Distilled water1.0 L
Malt extract10.0 g
Dextrose4.0 g
Adjust pH to 7.3.

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